P-selectin Plasma Levels and Genetic Variant Associated With Diabetic Retinopathy in African Americans

Am J Ophthalmol. 2015 Jun;159(6):1152-1160.e2. doi: 10.1016/j.ajo.2015.03.008. Epub 2015 Mar 17.

Abstract

Purpose: To report the prevalence and risk factors for retinopathy in African Americans with impaired fasting glucose (IFG) and type 2 diabetes in the Jackson Heart Study and to determine if P-selectin plasma levels are independently associated with retinopathy in this population.

Design: Prospective, cross-sectional observational study.

Methods: setting: Community-based epidemiologic study.

Study population: Total of 629 patients with type 2 diabetes and 266 participants with impaired fasting glucose.

Observation procedures: Bilateral, 7-field fundus photographs were scored by masked readers for diabetic retinopathy (DR) level. Covariate data including P-selectin plasma levels and genotypes were collected in a standardized fashion.

Main outcome measures: Association between risk factors, including P-selectin plasma levels and genotypes, and retinopathy.

Results: The prevalences of any retinopathy among participants with IFG and type 2 diabetes were 9.4% and 32.4%, respectively. Among those with type 2 diabetes, in multivariate models adjusted for age, sex, and other traditional risk factors, higher P-selectin levels were associated with any DR (odds ratio = 1.11, 95% confidence interval = 1.02-1.21, P = .02) and proliferative DR (odds ratio = 1.23, 95% confidence interval = 1.03-1.46, P = .02). To further investigate the relationship between P-selectin and DR, we examined the association between P-selectin genotype and DR. Minor allele homozygotes for the variant rs6128 were less likely to develop DR (P after Bonferroni correction = 0.03).

Conclusions: Both serologic and genetic data show an association between P-selectin and DR in the Jackson Heart Study. If confirmed in other studies, this association may provide insight into the pathogenesis of retinopathy.

Publication types

  • Observational Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • African Americans / ethnology*
  • Aged
  • Blood Glucose / metabolism
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications
  • Diabetic Retinopathy / blood
  • Diabetic Retinopathy / ethnology*
  • Diabetic Retinopathy / genetics
  • Female
  • Genotype
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Male
  • Middle Aged
  • P-Selectin / blood*
  • P-Selectin / genetics*
  • Polymorphism, Single Nucleotide*
  • Prevalence
  • Prospective Studies
  • Risk Factors
  • United States / epidemiology

Substances

  • Blood Glucose
  • Glycated Hemoglobin A
  • P-Selectin
  • SELP protein, human
  • hemoglobin A1c protein, human