IL-17 and neutrophils: unexpected players in the type 2 immune response

Curr Opin Immunol. 2015 Jun;34:99-106. doi: 10.1016/j.coi.2015.03.001. Epub 2015 Mar 18.

Abstract

The study of immunity to helminth infection has been central to understanding the function of type 2 cytokines and their targets. Although type 2 cytokines are considered anti-inflammatory and promote tissue repair, they also contribute to allergy and fibrosis. Here, we utilise data from helminth infection models, to illustrate that IL-17 and neutrophils, typically associated with pro-inflammatory responses, are intimately linked with type 2 immunity. Neutrophils work with IL-4Rα-activated macrophages to control incoming larvae but this comes at a cost of enhanced tissue damage. Chitinase like proteins (CLPs) bridge these diverse outcomes, inducing both protective IL-17 and reparative Th2 responses. Dysregulation of CLPs, IL-17 and neutrophils likely contribute to disease severity and pathology associated with type 2 immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytokines / immunology
  • Humans
  • Interleukin-17 / immunology*
  • Neutrophils / immunology*
  • Strongylida / classification
  • Strongylida / physiology*
  • Strongylida Infections / immunology*
  • Strongylida Infections / parasitology

Substances

  • Cytokines
  • Interleukin-17