Bone-adiposity cross-talk: implications for pediatric obesity. A narrative review of literature

J Bone Miner Metab. 2015 Nov;33(6):592-602. doi: 10.1007/s00774-015-0654-6. Epub 2015 Mar 22.


The rising prevalence of overweight and obesity among pediatric populations has become a major global concern. The objective of this review is to demonstrate potential interactions between the products released by fat tissue and the hormonal production of bone tissue in obese children and adolescents. Advancing the understanding of the complex interactions between adipocyte and osteocyte activities may contribute to the mechanistic understanding of the body's responses to weight loss during adolescence. This knowledge could also reveal any side effects encountered with these interventions. Currently, the concept of bone-adiposity crosstalk has not been fully elucidated, and the mechanisms remain controversial. Understanding the local interactions between the released products by fat tissue and hormones produced in bone tissue requires further investigations.

Keywords: Adipocyte; Adolescents; Obesity; Osteocyte.

Publication types

  • Review

MeSH terms

  • Adipocytes / pathology
  • Adiposity*
  • Adolescent
  • Humans
  • Organ Size
  • Pediatric Obesity / pathology*
  • Weight Loss