Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn

Brain Res. 1985 Jan 28;325(1-2):294-8. doi: 10.1016/0006-8993(85)90326-9.


Effects of various types of natural skin stimuli on the in situ release of immunoreactive substance P and somatostatin from the rabbit dorsal horn were examined. Noxious mechanical or thermal stimuli specifically increased the release of immunoreactive substance P or somatostatin, respectively. Innocuous stimuli did not affect the release of these peptides. These results suggest that the nociceptive mechanical or thermal primary afferents contain substance P or somatostatin, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Hot Temperature / adverse effects
  • Male
  • Nociceptors / physiology
  • Pain / physiopathology*
  • Physical Stimulation
  • Rabbits
  • Somatostatin / physiology*
  • Spinal Cord / physiopathology*
  • Substance P / physiology*
  • Synaptic Transmission
  • Thermoreceptors / physiology


  • Substance P
  • Somatostatin