Behavioral and cognitive effects of tyrosine intake in healthy human adults

Pharmacol Biochem Behav. 2015 Jun:133:1-6. doi: 10.1016/j.pbb.2015.03.008. Epub 2015 Mar 20.


The amino acid tyrosine is the precursor to the catecholamine neurotransmitters dopamine and norepinephrine. Increasing tyrosine uptake may positively influence catecholamine-related psychological functioning. We conducted a systematic review to examine the effects of tyrosine on behavior and cognition. Fifteen studies were reviewed. All studies except one involved tyrosine loading during a single test session. In most behavioral studies, there were no significant effects of tyrosine on exercise performance. In contrast, cognitive studies employing neuropsychological measures found that tyrosine loading acutely counteracts decrements in working memory and information processing that are induced by demanding situational conditions such as extreme weather or cognitive load. The buffering effects of tyrosine on cognition may be explained by tyrosine's ability to neutralize depleted brain catecholamine levels. There is evidence that tyrosine may benefit healthy individuals exposed to demanding situational conditions. For future research we recommend moving from studying the acute effects of a single tyrosine load in small samples to studying the behavioral and cognitive effects of tyrosine in larger groups over multiple weeks.

Keywords: Behavior; Catecholamines; Cognition; Dietary supplement; Human participants; Tyrosine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Brain / drug effects
  • Brain / metabolism
  • Cognition / drug effects*
  • Emotions / drug effects
  • Exercise Test / drug effects*
  • Humans
  • Norepinephrine / metabolism
  • Tyrosine / pharmacology*


  • Tyrosine
  • Norepinephrine