[Regulation of angiogenesis and tumor growth]

Abstract

The data on tumour vascularization regulating substances, their structure and mechanism of action are reviewed. The systems for testing angiogenic reactions are analyzed. The role of mast cells, lymphocytes, macrophages and leucocytes in formation of new microvessels is under discussion. The results of the search for antitumor drugs inhibiting angiogenesis are promising. The data are analyzed on the role of prostaglandins, Cu2+ and urokinase in the processes of tumour vascularization. The possibility of the complex and multifactor regulation of microvessels is suggested.