Use of surface-enhanced Raman scattering as a prognostic indicator of acute kidney transplant rejection

Biomed Opt Express. 2015 Feb 10;6(3):761-9. doi: 10.1364/BOE.6.000761. eCollection 2015 Mar 1.


We report an early, noninvasive and rapid prognostic method of predicting potential acute kidney dysfunction using surface-enhanced Raman scattering (SERS). Our analysis was performed on urine samples collected prospectively from 58 kidney transplant patients using a He-Ne laser (632.8 nm) as the excitation source. All abnormal kidney function episodes (three acute rejections and two acute kidney failures that were eventually diagnosed independently by clinical biopsy) consistently exhibited unique SERS spectral features in just one day following the transplant surgery. These results suggested that SERS analysis provides an early and more specific indication to kidney function than the clinically used biomarker, serum creatinine (sCr).

Keywords: (160.4236) Nanomaterials; (170.5660) Raman spectroscopy; (170.6510) Spectroscopy, tissue diagnostics; (240.6695) Surface-enhanced Raman scattering.