Dementia: Cognitive resilience in APOE*ε4 carriers—is race important?

Nat Rev Neurol. 2015 Apr;11(4):190-1. doi: 10.1038/nrneurol.2015.38. Epub 2015 Mar 24.


The apolipoprotein E ε4 (APOE*ε4) allele is a well-established risk factor for cognitive decline, particularly among white individuals. A recent study highlights factors associated with cognitive resilience in both black and white APOE*ε4 carriers. Despite racial differences in the frequency and impact of APOE*ε4, resilience factors are similar across races.

Publication types

  • News
  • Comment

MeSH terms

  • Aging / genetics*
  • Apolipoproteins E / genetics*
  • Black People / genetics*
  • Cognition / physiology*
  • Female
  • Humans
  • Male
  • Risk Reduction Behavior*
  • White People / genetics*


  • Apolipoproteins E