Significance of antikeratin antibodies in rheumatoid arthritis

J Rheumatol. 1985 Feb;12(1):57-9.


Antikeratin antibodies (AKA) were found in the sera of 59% (121/204) of patients with rheumatoid arthritis (RA). There was a significantly higher incidence of AKA (73%) in male patients compared with females (53%) and a correlation between AKA positivity and IgM rheumatoid factor was found. Antibody reactivity was positively associated with the presence of nodules, antinuclear antibody, C-reactive protein and disease severity. AKA would appear to have possible prognostic significance in patients with RA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / analysis
  • Antibodies / immunology*
  • Antibodies, Antinuclear / analysis
  • Arthritis, Rheumatoid / immunology*
  • Arthritis, Rheumatoid / physiopathology
  • Female
  • Humans
  • Immunoglobulin M / analysis
  • Keratins / immunology*
  • Male
  • Middle Aged
  • Rheumatoid Factor / analysis


  • Antibodies
  • Antibodies, Antinuclear
  • Immunoglobulin M
  • Keratins
  • Rheumatoid Factor