NAD in RNA: unconventional headgear

Daniel J Luciano; Joel G Belasco

doi:10.1016/j.tibs.2015.03.004

NAD in RNA: unconventional headgear

Trends Biochem Sci. 2015 May;40(5):245-7. doi: 10.1016/j.tibs.2015.03.004. Epub 2015 Mar 21.

Authors

Daniel J Luciano¹, Joel G Belasco²

Affiliations

¹ Kimmel Center for Biology and Medicine at the Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
² Kimmel Center for Biology and Medicine at the Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA. Electronic address: joel.belasco@med.nyu.edu.

Abstract

Although widely assumed to bear a 5'-terminal triphosphate or monophosphate, recent evidence suggests that the 5' end of bacterial RNA can sometimes bear a modification reminiscent of a eukaryotic cap. A new study has now identified Escherichia coli RNAs that begin with a noncanonical cap resembling the redox cofactor nicotinamide adenine dinucleotide (NAD), as well as a cellular enzyme that can remove it. The biological function of such caps remains to be determined.

Keywords: NudC; RNA I; RNA degradation; RNase E; RppH; sRNA.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Escherichia coli / genetics*
Escherichia coli / metabolism*
Escherichia coli Proteins / genetics
Escherichia coli Proteins / metabolism
NAD / chemistry*
RNA, Bacterial / chemistry*
RNA, Bacterial / metabolism

Substances

Escherichia coli Proteins
RNA, Bacterial
NAD

Abstract

Publication types

MeSH terms

Substances

Grants and funding