Corticostriatal BDNF and alcohol addiction

Brain Res. 2015 Dec 2;1628(Pt A):60-7. doi: 10.1016/j.brainres.2015.03.025. Epub 2015 Mar 21.


Growth factors, long studied for their involvement in neuronal development and plasticity, also regulate responses to drugs of abuse, including alcohol. This review details the intricate interaction between the Brain-Derived Neurotrophic Factor (BDNF) and alcohol, and provides evidence to suggest that corticostriatal BDNF signaling acts to keep alcohol drinking in moderation. Specifically, we describe studies in rodent models suggesting that moderate consumption of alcohol increases BDNF levels in the dorsal striatum, which in turn act to suppress alcohol intake by activating a Mitogen-Activated Protein Kinase (MAPK)-dependent genomic mechanism. We further provide data to suggest that alcohol intake levels escalate when the endogenous corticostriatal BDNF pathway becomes dysregulated. Finally, we summarize recent studies suggesting that specific microRNAs targeting BDNF mRNA in the medial prefrontal cortex (mPFC) regulate the breakdown of the protective corticostriatal BDNF pathway.

Keywords: Alcohol; BDNF; Dorsal striatum; Prefrontal cortex.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alcoholism / metabolism*
  • Animals
  • Brain-Derived Neurotrophic Factor / metabolism*
  • Central Nervous System Depressants / pharmacology
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism*
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism*
  • Ethanol / pharmacology
  • Neural Pathways / drug effects
  • Neural Pathways / metabolism


  • Brain-Derived Neurotrophic Factor
  • Central Nervous System Depressants
  • Ethanol