alpha 1-Microglobulin determination in urine for the early detection of renal tubular dysfunctions caused by exposure to cadmium

Toxicol Lett. Feb-Mar 1985;24(2-3):195-201. doi: 10.1016/0378-4274(85)90057-8.

Abstract

The determination of alpha 1-microglobulin (alpha 1-m) in urine was compared with that of beta 2-microglobulin (beta 2-m) for the detection of renal tubular dysfunctions caused by exposure to cadmium. alpha 1-m In urine is stable down to pH 4.5, whereas beta 2-m degrades below pH 5.5. The relationship between the urinary pH and alpha 1-m or beta 2-m in urine showed that alpha 1-m was independent of urinary pH, whereas beta 2-m-concentration decreased as urinary pH fell to a pH level below 6. Without a pH effect, alpha 1-m was highly correlated with beta 2-m in urine (N = 174, r = 0.96) from Cd-polluted subjects with renal dysfunctions. Due to the greater stability of alpha 1-m in urine, alpha 1-m seemed to be more advantageous than beta 2-m for the detection of renal tubular dysfunctions caused by Cd.

MeSH terms

  • Adult
  • Alpha-Globulins / urine*
  • Cadmium Poisoning / diagnosis*
  • Cadmium Poisoning / urine
  • Creatinine / urine
  • Environmental Exposure
  • Humans
  • Hydrogen-Ion Concentration
  • Kidney Diseases / chemically induced
  • Kidney Diseases / diagnosis
  • Kidney Diseases / urine
  • Kidney Tubules / physiopathology*
  • Middle Aged
  • beta 2-Microglobulin / urine

Substances

  • Alpha-Globulins
  • alpha-1-microglobulin
  • beta 2-Microglobulin
  • Creatinine