[Cognitive and emotional impairments in patients with protracted anxiety-phobic disorders]

Ter Arkh. 2014;86(12):61-5. doi: 10.17116/terarkh2014861261-65.
[Article in Russian]


Aim: To study cognitive and emotional impairments in patients with anxiety-phobic disorders (APDs), to comparatively analyze the clinical manifestations of acute (less than one-year) and protracted (1-to-5-year) forms of this disease, and to evaluate the efficacy of noofen used to treat this pathology.

Subjects and methods: Sixty-two patients aged 18 to 50 years with APDs were examined. The investigators collected clinical history data, performed neurological examination, and assessed autonomic disorders in accordance with the questionnaire to reveal their signs, anxiety using the Hamilton anxiety rating scale, memory impairment employing the methods developed by A.R. Luria, attention disorders applying the test of variables of attention, and diagnosed emotional intelligence using the Mayer-Salovey-Caruso emotional intelligence test. Noofen 1000 mg/day was used to treat the patients.

Results: Protracted APDs were shown to be characterized by the higher degree of psychosomatic symptoms and by more pronounced impairments in attention, memory, and emotional intelligence. The data of posttreatment clinical and psychological studiesare indicative of improvements in 73.3% of cases.

Conclusion: The findings may lead to the conclusion that noofen is highly effective in the treatment of patients with protracted APDs.

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Chronic Disease
  • Cognition Disorders* / drug therapy
  • Cognition Disorders* / etiology
  • Cognition Disorders* / physiopathology
  • Humans
  • Middle Aged
  • Phobic Disorders* / complications
  • Phobic Disorders* / drug therapy
  • Phobic Disorders* / physiopathology
  • Tranquilizing Agents / administration & dosage
  • Tranquilizing Agents / pharmacology*
  • Treatment Outcome
  • Young Adult
  • gamma-Aminobutyric Acid / administration & dosage
  • gamma-Aminobutyric Acid / analogs & derivatives*
  • gamma-Aminobutyric Acid / pharmacology


  • Tranquilizing Agents
  • gamma-Aminobutyric Acid
  • 4-amino-3-phenylbutyric acid