Virgin olive oil, palm olein and coconut oil diets do not raise cell adhesion molecules and thrombogenicity indices in healthy Malaysian adults

Eur J Clin Nutr. 2015 Jun;69(6):712-6. doi: 10.1038/ejcn.2015.26. Epub 2015 Mar 25.


Background/objectives: Effects of high-protein diets that are rich in saturated fats on cell adhesion molecules, thrombogenicity and other nonlipid markers of atherosclerosis in humans have not been firmly established. We aim to investigate the effects of high-protein Malaysian diets prepared separately with virgin olive oil (OO), palm olein (PO) and coconut oil (CO) on cell adhesion molecules, lipid inflammatory mediators and thromobogenicity indices in healthy adults.

Methods: A randomized cross-over intervention with three dietary sequences, using virgin OO, PO and CO as test fats, was carried out for 5 weeks on each group consisting of 45 men and women. These test fats were incorporated separately at two-thirds of 30% fat calories into high-protein Malaysian diets.

Results: For fasting and nonfasting blood samples, no significant differences were observed on the effects of the three test-fat diets on thrombaxane B2 (TXB2), TXB2/PGF1α ratios and soluble intracellular and vascular cell adhesion molecules. The OO diet induced significantly lower (P<0.05) plasma leukotriene B4 (LTB4) compared with the other two test diets, whereas PGF1α concentrations were significantly higher (P<0.05) at the end of the PO diet compared with the OO diet.

Conclusion: Diets rich in saturated fatty acids from either PO or CO and high in monounsaturated oleic acid from virgin OO do not alter the thrombogenicity indices-cellular adhesion molecules, thromboxane B2 (TXB2) and TXB2/prostacyclin (PGF1α) ratios. However, the OO diet lowered plasma proinflammatory LTB4, whereas the PO diet raised the antiaggregatory plasma PGF1α in healthy Malaysian adults. This trial was registered at as NCT 00941837.

Trial registration: NCT00941837.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Algorithms
  • Arecaceae / chemistry*
  • Biomarkers / blood
  • Cell Adhesion Molecules / blood*
  • Cell Adhesion Molecules / chemistry
  • Coconut Oil
  • Cross-Over Studies
  • Diet, High-Fat / adverse effects*
  • Diet, High-Fat / ethnology
  • Dietary Fats, Unsaturated / adverse effects*
  • Dietary Fats, Unsaturated / standards
  • Dietary Fats, Unsaturated / therapeutic use
  • Female
  • Humans
  • Leukotriene B4 / blood
  • Malaysia / epidemiology
  • Male
  • Middle Aged
  • Olive Oil / standards
  • Olive Oil / therapeutic use*
  • Plant Oils / adverse effects
  • Prostaglandins F / blood
  • Risk
  • Thrombosis / epidemiology
  • Thrombosis / ethnology
  • Thrombosis / etiology*
  • Thrombosis / prevention & control
  • Thromboxane B2 / blood
  • Triolein / adverse effects*
  • Young Adult


  • Biomarkers
  • Cell Adhesion Molecules
  • Dietary Fats, Unsaturated
  • Olive Oil
  • Plant Oils
  • Prostaglandins F
  • Triolein
  • Leukotriene B4
  • Thromboxane B2
  • Coconut Oil
  • prostaglandin F1

Associated data