Medication Type Modifies Inflammatory Response to Traffic Exposure in a Population With Type 2 Diabetes

Environ Pollut. 2015 Jul;202:58-65. doi: 10.1016/j.envpol.2015.03.012. Epub 2015 Mar 24.

Abstract

The association between residential traffic exposure and change in C-reactive protein over 2-years was evaluated using multivariate linear regression including interaction models for traffic and diabetes medication use/type (insulin vs. oral hypoglycemic agents (OHAs)). The study population was Puerto Rican adults (n = 356) residing in greater Boston with type 2 diabetes. Traffic was characterized as proximity to roads with >20,000 weekday traffic volumes, and multi-directional traffic density. Increases in CRP concentration were significantly associated with residence ≤100 m of a roadway (p = 0.009) or near multiple roadways (p < 0.001), vs. further away, for individuals using insulin in stratified models, with consistent results in interaction models (p = 0.071 and p = 0.002). CRP was significantly lower with highest traffic density exposure in stratified (p = 0.03) and interaction models (p = 0.024) for individuals using OHAs. Individuals on insulin experienced increased CRP concentrations with traffic exposure over a 2-year study period, while those using OHAs did not experience increases.

Keywords: C-reactive protein; Inflammation; Puerto Rican; Residential traffic exposure; Traffic density; Traffic proximity; Type 2 diabetes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Air Pollutants / analysis*
  • Air Pollutants / toxicity
  • Boston / epidemiology
  • C-Reactive Protein / metabolism
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / epidemiology
  • Environmental Monitoring
  • Female
  • Hispanic Americans
  • Housing
  • Humans
  • Hypoglycemic Agents / administration & dosage
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / administration & dosage
  • Insulin / therapeutic use*
  • Linear Models
  • Male
  • Vehicle Emissions / analysis*
  • Vehicle Emissions / toxicity

Substances

  • Air Pollutants
  • Hypoglycemic Agents
  • Insulin
  • Vehicle Emissions
  • C-Reactive Protein