Inhibition of insulin-like growth factor receptor: end of a targeted therapy?

Transl Lung Cancer Res. 2013 Feb;2(1):14-22. doi: 10.3978/j.issn.2218-6751.2012.11.05.


The Insulin-like Growth Factor 1 (IGF-1) signaling pathway activates several downstream signals important to lung cancer development and survival. IGF-1R activation has been linked to cancer risk in epidemiological studies and tumorigenesis in preclinical models. Several inhibitors of the insulin-like growth factor 1 receptor (IGF-1R) have been tested in clinical trials. Despite promising data in early phase studies, most studies of IGF-1R antagonists in combination with chemotherapy or with epidermal growth factor receptor (EGFR) inhibitors in non-small cell lung cancer (NSCLC) yielded disappointing results. Biomarker studies of clinical trials have identified IGF-1 levels as a potential marker of sensitivity to IGF-1R inhibition. Further study will need to focus on selection of NSCLC patients most likely to benefit from the addition of IGF-1R antagonists to standard therapy and the development of rational strategies for combination therapy in NSCLC.

Keywords: Insulin-like Growth Factor 1 (IGF-1); epidermal growth factor receptor (EGFR); insulin-like growth factor 1 receptor (IGF-1R); non-small cell lung cancer (NSCLC).

Publication types

  • Review