Intestinal infection with Mycobacterium avium in acquired immune deficiency syndrome (AIDS). Histological and clinical comparison with Whipple's disease

Dig Dis Sci. 1985 May;30(5):497-504. doi: 10.1007/BF01318186.

Abstract

At endoscopy, a 30-year-old man with acquired immune deficiency syndrome (AIDS), Kaposi's sarcoma, diarrhea, and unexplained malabsorption showed erythematous macular duodenal lesions consistent with Whipple's disease by histology and electron microscopy. Symptoms did not respond to tetracycline. Subsequent cultures revealed systemic Mycobacterium avium (M. avium) infection. Tissue from this patient, from patients with Whipple's disease and from a macaque with M. avium were compared. All contained PAS-positive macrophages but M. avium could be distinguished by positive acid-fast stains and a difference in pattern of indirect immunofluorescence staining with bacterial typing antisera. PAS-positive macrophages in the intestinal lamina propria are no longer pathognomonic of Whipple's disease. Ultrastructural and histological similarities between Whipple's disease and M. avium infection suggest that both are manifestations of immune deficits limiting macrophage destruction of particular bacteria after phagocytosis. M. avium must be considered in the differential diagnosis of diarrhea in patients with AIDS and other immunosuppressed conditions.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / pathology
  • Adult
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Body Weight
  • Diarrhea / etiology
  • Duodenal Diseases / complications
  • Duodenal Diseases / microbiology*
  • Duodenal Diseases / pathology
  • Endoscopy
  • Fluorescent Antibody Technique
  • Homosexuality
  • Humans
  • Lymph Nodes / microbiology
  • Macaca
  • Macrophages / microbiology
  • Male
  • Mycobacterium avium / immunology
  • Sarcoma, Kaposi / drug therapy
  • Sarcoma, Kaposi / pathology
  • Tuberculosis, Gastrointestinal / complications*
  • Tuberculosis, Gastrointestinal / immunology
  • Tuberculosis, Gastrointestinal / pathology
  • Whipple Disease / immunology
  • Whipple Disease / pathology