Factors associated with patient and provider delays for tuberculosis diagnosis and treatment in Asia: a systematic review and meta-analysis

PLoS One. 2015 Mar 25;10(3):e0120088. doi: 10.1371/journal.pone.0120088. eCollection 2015.

Abstract

Background: Delays in tuberculosis (TB) diagnosis and treatment is a major barrier to effective management of the disease. Determining the factors associated with patient and provider delay of TB diagnosis and treatment in Asia may contribute to TB prevention and control.

Methods: We searched the PubMed, EMBASE and Web of Science for studies that assessed factors associated with delays in care-seeking, diagnosis, or at the beginning of treatment, which were published from January 1992 to September 2014. Two reviewers independently identified studies that were related to our meta-analysis and extracted data from each study. Independent variables were categorized in separate tables for patient and provider delays.

Results: Among 45 eligible studies, 40 studies assessed patient delay whereas 30 assessed provider delay. Cross-sectional surveys were used in all but two articles, which included 17 countries and regions. Socio-demographic characteristics, TB-related symptoms and medical examination, and conditions of seeking medical care in TB patients were frequently reported. Male patients and long travel time/distance to the first healthcare provider led to both shorter patient delays [odds ratio (OR) (95% confidence intervals, CI) = 0.85 (0.78, 0.92); 1.39 (1.08, 1.78)] and shorter provider delays [OR (95%CI) = 0.96 (0.93, 1.00); 1.68 (1.12, 2.51)]. Unemployment, low income, hemoptysis, and positive sputum smears were consistently associated with patient delay [ORs (95%CI) = 1.18 (1.07, 1.30), 1.23 (1.02, 1.49), 0.64 (0.40, 1.00), 1.77 (1.07, 2.94), respectively]. Additionally, consultation at a public hospital was associated with provider delay [OR (95%CI) = 0.43 (0.20, 0.91)].

Conclusions: We propose that the major opportunities to reduce delays involve enabling socio-demographic factors and medical conditions. Male, unemployed, rural residence, low income, hemoptysis, positive sputum smear, and long travel time/distance significantly correlated with patient delay. Male, long travel time/distance and consultation at a public hospital were related to provider delay.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Asia
  • Cross-Sectional Studies
  • Databases, Factual
  • Delayed Diagnosis
  • Humans
  • Odds Ratio
  • Public Health
  • Sex Factors
  • Socioeconomic Factors
  • Sputum / microbiology
  • Tuberculosis / diagnosis*
  • Tuberculosis / therapy

Grant support

The authors thank The National Natural Science Funds (81172662/H2603) (http://159.226.244.22/portal/Proj_List.asp) and Specialized Research Fund for the Doctoral Program of Higher Education (20123706110004) (http://www.cutech.edu.cn/cn/kyjj/gdxxbsdkyjj/2013/02/1354173488080563.htm) for the grants supporting the study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.