An n=1 case report of a child with autism improving on antibiotics and a father's quest to understand what it may mean

Microb Ecol Health Dis. 2015 Mar 24;26:26382. doi: 10.3402/mehd.v26.26382. eCollection 2015.


The author, a parent of a child with autism, describes an n=1 case in which his child's autism symptoms dramatically and rapidly improved following administration of a common antibiotic. The author asserts that this finding is not unusual in the autism population and that, when combined with prior recent medical research, suggests that a link between autism and the microbiome in some children is not just plausible, but in fact likely for some meaningful percentage of cases. The author argues for increased funding for a more thorough examination of links between autism and the microbiome and poses a series of questions to be further examined in future research.

Keywords: N of One; amoxicillin; antibiotic; autism; microbiome; n=1; vancomycin.