Monoamine oxidase a promoter variable number of tandem repeats (MAOA-uVNTR) in alcoholics according to Lesch typology

Int J Environ Res Public Health. 2015 Mar 19;12(3):3317-26. doi: 10.3390/ijerph120303317.

Abstract

Background: The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch's typology.

Methods: DNA was provided from alcohol dependent (AD) patients (n=370) and healthy control subjects (n=168) all of Polish descent. The history of alcoholism was obtained using the Polish version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Samples were genotyped using PCR methods.

Results: We found no association between alcohol dependence and MAOA gene polymorphism.

Conclusions: Lesch typology is a clinical consequence of the disease and its phenotypic description is too complex for a simple genetic analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alcoholism / genetics*
  • Case-Control Studies
  • Female
  • Genetic Markers
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Minisatellite Repeats*
  • Monoamine Oxidase / genetics*
  • Polymorphism, Genetic*
  • Promoter Regions, Genetic*

Substances

  • Genetic Markers
  • Monoamine Oxidase
  • monoamine oxidase A, human