The 2011-2014 prevalence of eosinophilic oesophagitis in the elderly amongst 10 million patients in the United States

Aliment Pharmacol Ther. 2015 May;41(10):1016-22. doi: 10.1111/apt.13171. Epub 2015 Mar 23.


Background: Eosinophilic oesophagitis (EoE) is primarily diagnosed by clinicians. There are less than a handful of epidemiological studies in EoE that have included elderly patients (>65 years).

Aim: To determine the prevalence of elderly subjects among EoE patients and compare their clinical presentation, associated conditions and treatment modalities with adult and paediatric EoE patients.

Methods: A large nationwide database (Explorys) between January 2011 and January 2014 was used. The term 'Eosinophilic Oesophagitis' was used in the Explorys search tool. The patient population was divided into three groups, Paediatric (<18 years), Adult (18-65 years) and Elderly (>65 years).

Results: We identified 4840 patients coded as EoE. The total estimated prevalence was 50.6 cases per 100 000 patients (0.05%). A total of 360 cases (7.44%) were elderly patients with an estimated prevalence rate of 18.6 cases per 100 000. Across all age groups, the majority of EoE patients were Caucasians and males. A significantly greater proportion of older patients had concomitant GERD. Dysphagia was the most common symptom among elderly EoE patients as compared with the paediatric EoE patients (P < 0.001). The proportion of elderly EoE patients with food allergies or asthma was significantly lower as compared with paediatric and adult EoE patients (P < 0.001). Oesophageal dilation and/or proton pump inhibitor treatment were the most commonly used therapeutic modalities in elderly EoE patients.

Conclusion: Eosinophilic oesophagitis is uncommon in elderly subjects and the clinical presentation is markedly different as compared with adults or the paediatric population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Asthma / epidemiology
  • Child
  • Databases, Factual
  • Deglutition Disorders / epidemiology*
  • Deglutition Disorders / etiology
  • Dilatation / methods
  • Eosinophilic Esophagitis / epidemiology*
  • Eosinophilic Esophagitis / physiopathology
  • Eosinophilic Esophagitis / therapy
  • Female
  • Food Hypersensitivity / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Proton Pump Inhibitors / therapeutic use*
  • United States / epidemiology
  • Young Adult


  • Proton Pump Inhibitors