Influence of the complex of retinol-vitamin C on skin surface lipids

J Cosmet Dermatol. 2015 Jun;14(2):92-9. doi: 10.1111/jocd.12140. Epub 2015 Mar 24.


Background: Retinol is used to reduce symptoms of skin aging. It affects surface lipids and increases skin regeneration ability.

Aim: The aim of our study was to investigate the effect of retinol peel on the face and neck skin lipids in women, aged 50-69.

Material and methods: The level of secreted sebum was measured using Sebumeter SM15 (Courage & Khazaka, Germany) on the forehead, cheeks, nose, chin, and neck. The measurements were carried out before each of the 3 retinol peel treatments applied at 3-week interval and 3 weeks after the last treatment.

Results: A statistically significant increase of lipid film in both U-zone and T-zone and on the neck was observed in the study group.

Conclusion: Retinol peel treatments can help to increase the amount of skin surface lipids in women during menopause.

Keywords: l-ascorbic acid; menopause; retinol; sebumeter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Ascorbic Acid / pharmacology*
  • Face
  • Female
  • Humans
  • Lipid Metabolism / drug effects*
  • Middle Aged
  • Neck
  • Sebum / metabolism
  • Skin / metabolism*
  • Skin Aging / drug effects
  • Vitamin A / chemistry
  • Vitamin A / pharmacology*
  • Vitamins / pharmacology*


  • Vitamins
  • Vitamin A
  • Ascorbic Acid