Opioid hypofunction in Parkinson's disease

Med Hypotheses. 1985 Feb;16(2):179-82. doi: 10.1016/0306-9877(85)90074-x.

Abstract

Loss of dopaminergic neuronal function has been the most consistent biochemical abnormality found in Parkinson's disease. Hypofunction of other transmitter systems has also been demonstrated in this disease. Recently, an opioid-dopamine link has been demonstrated. This paper provides evidence supporting an opioid system hypofunction in Parkinson's disease.

MeSH terms

  • Acetylcholine / physiology
  • Animals
  • Brain / physiopathology*
  • Dopamine / physiology
  • Endorphins / physiology*
  • Neurotransmitter Agents / physiology*
  • Parkinson Disease / physiopathology*
  • Rats
  • Serotonin / physiology
  • Substance P / physiology
  • Synaptic Transmission
  • gamma-Aminobutyric Acid / physiology

Substances

  • Endorphins
  • Neurotransmitter Agents
  • Serotonin
  • Substance P
  • gamma-Aminobutyric Acid
  • Acetylcholine
  • Dopamine