Abstract
Subacute sclerosing panencephalitis (SSPE) is a neurodegenerative disease of childhood that is due to a persistent measles infection. Owing to a nationwide immunization program in the United States, the incidence has decreased considerable, coexistent with the decline in natural measles infection. The disease, now fully understood, still represents a great international problem. Clinical presentation, etiology, pathogenesis, prevention, and treatment are updated in this article.
MeSH terms
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Adolescent
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Amantadine / therapeutic use
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Antibodies, Viral / cerebrospinal fluid
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Brain / pathology
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Child
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Child, Preschool
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Electroencephalography
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Female
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Humans
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Inosine Pranobex / therapeutic use
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Male
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Measles virus / immunology
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Palliative Care
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Registries
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Rural Population
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Subacute Sclerosing Panencephalitis / diagnosis*
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Subacute Sclerosing Panencephalitis / epidemiology
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Subacute Sclerosing Panencephalitis / therapy
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Viral Proteins / immunology
Substances
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Antibodies, Viral
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Viral Proteins
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Amantadine
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Inosine Pranobex