Subacute Sclerosing Panencephalitis. Current Status

Neurol Clin. 1985 Feb;3(1):179-96.

Abstract

Subacute sclerosing panencephalitis (SSPE) is a neurodegenerative disease of childhood that is due to a persistent measles infection. Owing to a nationwide immunization program in the United States, the incidence has decreased considerable, coexistent with the decline in natural measles infection. The disease, now fully understood, still represents a great international problem. Clinical presentation, etiology, pathogenesis, prevention, and treatment are updated in this article.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Amantadine / therapeutic use
  • Antibodies, Viral / cerebrospinal fluid
  • Brain / pathology
  • Child
  • Child, Preschool
  • Electroencephalography
  • Female
  • Humans
  • Inosine Pranobex / therapeutic use
  • Male
  • Measles virus / immunology
  • Palliative Care
  • Registries
  • Rural Population
  • Subacute Sclerosing Panencephalitis / diagnosis*
  • Subacute Sclerosing Panencephalitis / epidemiology
  • Subacute Sclerosing Panencephalitis / therapy
  • Viral Proteins / immunology

Substances

  • Antibodies, Viral
  • Viral Proteins
  • Amantadine
  • Inosine Pranobex