Disordered sleep and myopia risk among Chinese children

PLoS One. 2015 Mar 26;10(3):e0121796. doi: 10.1371/journal.pone.0121796. eCollection 2015.

Abstract

Purpose: Disordered sleep and myopia are increasingly prevalent among Chinese children. Similar pathways may be involved in regulation of both sleep cycles and eye growth. We therefore sought to examine the association between disordered sleep and myopia in this group.

Methods: Urban primary school children participating in a clinical trial on myopia and outdoor activity underwent automated cycloplegic refraction with subjective refinement. Parents answered questions about children's sleep duration, sleep disorders (Children's Sleep Habits Questionnaire [CSHQ]), near work and time spent outdoors.

Results: Among 1970 children, 1902 (96.5%, mean [standard deviation SD] age 9.80 [0.44] years, 53.1% boys) completed refraction and questionnaires. Myopia < = -0.50 Diopters was present in both eyes of 588 (30.9%) children (1329/3804 = 34.9% of eyes) and 1129 children (59.4%) had abnormal CSHQ scores (> 41). In logistic regression models by eye, odds of myopia < = -0.50D increased with worse CSHQ score (Odds Ratio [OR] 1.01 per point, 95% Confidence Interval [CI] [1.001, 1.02], P = 0.014) and more night-time sleep (OR 1.02, 95% CI [1.01, 1.04, P = 0.002], while male sex (OR 0.82, 95% CI [0.70, 0.95], P = 0.008) and time outdoors (OR = 0.97, 95% CI [0.95, 0.99], P = 0.011) were associated with less myopia. The association between sleep duration and myopia was not significant (p = 0.199) for total (night + midday) sleep.

Conclusions: Myopia and disordered sleep were both common in this cohort, but we did not find consistent evidence for an association between the two.

Trial registration: clinicaltrials.gov NCT00848900.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian Continental Ancestry Group / statistics & numerical data*
  • Child
  • China / epidemiology
  • Cohort Studies
  • Cross-Sectional Studies
  • Demography
  • Female
  • Humans
  • Logistic Models
  • Male
  • Myopia / complications*
  • Myopia / epidemiology*
  • Myopia / physiopathology
  • Randomized Controlled Trials as Topic
  • Refractive Errors / complications
  • Refractive Errors / epidemiology
  • Refractive Errors / physiopathology
  • Risk Factors
  • Sleep Wake Disorders / complications*
  • Sleep Wake Disorders / epidemiology*
  • Sleep Wake Disorders / physiopathology
  • Surveys and Questionnaires
  • Visual Acuity

Associated data

  • ClinicalTrials.gov/NCT00848900

Grant support

Supported by the Basic Research Fund for the State Key Laboratory at Zhongshan Ophthalmic Center. Prof Congdon is supported by a grant from the Government of China's Thousand Man Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.