Two paths to fat

Nat Cell Biol. 2015 Apr;17(4):360-1. doi: 10.1038/ncb3133.


Excess caloric intake leads to both the growth of existing fat cells and the generation of new adipocytes. New findings show that PI3K-Akt2 signalling is involved in the differentiation of adult adipose precursor cells—a pathway not required for adipogenesis in the embryo.

Publication types

  • Comment

MeSH terms

  • Adipocytes, White / cytology*
  • Adipogenesis / physiology*
  • Animals
  • Male
  • Obesity / metabolism*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Proto-Oncogene Proteins c-akt / metabolism*


  • Phosphatidylinositol 3-Kinases
  • Akt2 protein, mouse
  • Proto-Oncogene Proteins c-akt