Phytochemical profile and therapeutic potential of Viscum album L

Nat Prod Res. 2016;30(4):373-85. doi: 10.1080/14786419.2015.1022776. Epub 2015 Mar 27.

Abstract

Viscum album L., the European mistletoe, is a common species from the Viscaceae family. This evergreen hemiparasitic shrub grows on various trees and contains diverse, biologically active substances. Its chemical composition may vary depending on the time of harvest, species of the host tree and the manufacturing process. Among well-described and most active phytochemicals identified in V. album are lectins and viscotoxins, which play substantial role in cancer treatment because of their apoptotic and cytotoxic effects. Another group of compounds found in mistletoe are phenolic acids, phenylpropanoids and flavonoids with antioxidant and anti-inflammatory activities, which decrease blood pressure. Other mistletoe components include, among others, triterpenes with cytotoxic and apoptotic properties, and phytosterols, oligo- and polysaccharides. Extracts from the plant, especially aqueous, are applied in traditional and official medicine, among others in treating hypertension or arthritis. Potentially, it can also be used as a hepatoprotective or a sedative drug.

Keywords: European mistletoe; Viscum album L. ssp. album, ssp. abietis, ssp. austriacum; biologically activity; chemical composition.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Antioxidants
  • Humans
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use*
  • Viscum album / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Antioxidants
  • Plant Extracts