Prophylactic antibiotics and prevention of surgical site infections

Surg Clin North Am. 2015 Apr;95(2):269-83. doi: 10.1016/j.suc.2014.11.006. Epub 2015 Jan 10.


Healthcare-associated infections present a significant source of preventable morbidity and mortality. More than 30% of all healthcare-associated infections are represented by surgical site infections, making them the most common subtype. Studies suggest that 40% to 60% of these infections are preventable, yet many hospitals have yet to implement evidence-based best practices. This article reviews the impact of surgical site infections, describes their measurement and reporting, and most importantly provides perioperative strategies for their prevention with a focus on the appropriate use of prophylactic antibiotics.

Keywords: Perioperative infection control; Prophylactic antibiotics; Surgical site infection.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Antibiotic Prophylaxis*
  • Humans
  • Perioperative Care*
  • Surgical Wound Infection / economics
  • Surgical Wound Infection / epidemiology
  • Surgical Wound Infection / prevention & control*


  • Anti-Bacterial Agents