Detection of Autoantibodies Against Myelin Oligodendrocyte Glycoprotein in Multiple Sclerosis and Related Diseases

Methods Mol Biol. 2016;1304:99-104. doi: 10.1007/7651_2015_223.


Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) occur in a proportion of patients with different inflammatory demyelinating diseases of the central nervous system, such as childhood multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), and neuromyelitis optica spectrum disorders (NMOSD). We describe here in detail a sensitive cell-based assay that allows the identification of autoantibodies against MOG in serum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / blood
  • Autoantibodies / immunology*
  • Encephalomyelitis, Acute Disseminated / blood
  • Encephalomyelitis, Acute Disseminated / immunology
  • Humans
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / immunology*
  • Myelin-Oligodendrocyte Glycoprotein / immunology*
  • Neuromyelitis Optica / blood
  • Neuromyelitis Optica / immunology


  • Autoantibodies
  • Myelin-Oligodendrocyte Glycoprotein