Fibrous bodies in growth hormone-secreting adenomas contain cytokeratin filaments

Arch Pathol Lab Med. 1985 Jun;109(6):505-8.


Fibrous bodies in growth hormone-secreting adenomas were studied by immunocytochemistry using an anti-cytokeratin antiserum. Fibrous bodies are a feature of acidophil and chromophobe adenomas and are usually associated with acromegaly. Ultrastructural examination revealed round juxtanuclear filamentous aggregates, composed of 8-nm filaments and other organelles. This study demonstrated that the intermediate filaments of fibrous bodies belong to the cytokeratin class. The etiology and significance of these filamentous aggregates remain obscure.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoma / metabolism
  • Adenoma / ultrastructure*
  • Cytoskeleton / ultrastructure*
  • Female
  • Growth Hormone / metabolism*
  • Humans
  • Immunoenzyme Techniques
  • Keratins / analysis*
  • Middle Aged
  • Organoids / ultrastructure
  • Pituitary Neoplasms / metabolism
  • Pituitary Neoplasms / ultrastructure*


  • Keratins
  • Growth Hormone