Modelling the effect of SPION size in a stent assisted magnetic drug targeting system with interparticle interactions

ScientificWorldJournal. 2015;2015:618658. doi: 10.1155/2015/618658. Epub 2015 Mar 1.

Abstract

Cancer is a leading cause of death worldwide and it is caused by the interaction of genomic, environmental, and lifestyle factors. Although chemotherapy is one way of treating cancers, it also damages healthy cells and may cause severe side effects. Therefore, it is beneficial in drug delivery in the human body to increase the proportion of the drugs at the target site while limiting its exposure at the rest of body through Magnetic Drug Targeting (MDT). Superparamagnetic iron oxide nanoparticles (SPIONs) are derived from polyol methods and coated with oleic acid and can be used as magnetic drug carrier particles (MDCPs) in an MDT system. Here, we develop a mathematical model for studying the interactions between the MDCPs enriched with three different diameters of SPIONs (6.6, 11.6, and 17.8 nm) in the MDT system with an implanted magnetizable stent using different magnetic field strengths and blood velocities. Our computational analysis allows for the optimal design of the SPIONs enriched MDCPs to be used in clinical applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / blood
  • Antineoplastic Agents / pharmacokinetics
  • Blood Flow Velocity
  • Drug Carriers / chemistry
  • Drug Delivery Systems / methods*
  • Humans
  • Magnetic Fields
  • Magnetite Nanoparticles / chemistry
  • Magnetite Nanoparticles / therapeutic use*
  • Magnetite Nanoparticles / ultrastructure
  • Models, Theoretical
  • Neoplasms / blood
  • Neoplasms / drug therapy
  • Particle Size
  • Stents

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Magnetite Nanoparticles