Modeling human nutrition using human embryonic stem cells

Cell. 2015 Mar 26;161(1):12-17. doi: 10.1016/j.cell.2015.02.039.


Nutrition presents unanswered scientific questions of high public health importance. We envision model systems composed of interacting gastrointestinal and metabolic tissues derived from human embryonic stem cells, populated by gut microbiota. The culture will be embedded in 3D scaffolds, creating a controlled experimental system that enables tissue sampling and imaging.

MeSH terms

  • Animals
  • Diet
  • Embryonic Stem Cells / cytology*
  • Gastrointestinal Tract / microbiology
  • Gastrointestinal Tract / physiology*
  • Humans
  • Models, Animal
  • Models, Biological*
  • Nutritional Physiological Phenomena