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, 161 (1), 119-132

The Hunger Genes: Pathways to Obesity


The Hunger Genes: Pathways to Obesity

Agatha A van der Klaauw et al. Cell.


The global rise in the prevalence of obesity and associated co-morbidities such as type 2 diabetes, cardiovascular disease, and cancer represents a major public health concern. The biological response to increased consumption of palatable foods or a reduction in energy expenditure is highly variable between individuals. A more detailed mechanistic understanding of the molecular, physiological, and behavioral pathways involved in the development of obesity in susceptible individuals is critical for identifying effective mechanism-based preventative and therapeutic interventions.

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