Neural control of energy balance: translating circuits to therapies

Cell. 2015 Mar 26;161(1):133-145. doi: 10.1016/j.cell.2015.02.023.


Recent insights into the neural circuits controlling energy balance and glucose homeostasis have rekindled the hope for development of novel treatments for obesity and diabetes. However, many therapies contribute relatively modest beneficial gains with accompanying side effects, and the mechanisms of action for other interventions remain undefined. This Review summarizes current knowledge linking the neural circuits regulating energy and glucose balance with current and potential pharmacotherapeutic and surgical interventions for the treatment of obesity and diabetes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Appetite Depressants / therapeutic use
  • Brain / physiopathology
  • Diabetes Complications / drug therapy
  • Diabetes Complications / metabolism
  • Energy Metabolism* / drug effects
  • Humans
  • Neural Pathways* / drug effects
  • Obesity / drug therapy
  • Obesity / metabolism


  • Appetite Depressants