SnapShot: GI tract development

Cell. 2015 Mar 26;161(1):176-176.e1. doi: 10.1016/j.cell.2015.03.014.


The endoderm germ layer contributes to the respiratory and gastrointestinal (GI) lineages during development, giving rise to an array of specialized epithelial cell types lining organs, including the thyroid, thymus, lungs, liver, biliary system, pancreas, and intestines. This SnapShot timelines and summarizes key stages following gastrulation, including endoderm patterning, organ specification, and organogenesis. A lineage tree of the developing endocrine pancreas is outlined to further illustrate this process.

MeSH terms

  • Animals
  • Gastrointestinal Tract / cytology
  • Gastrointestinal Tract / embryology*
  • Gastrointestinal Tract / metabolism
  • Humans
  • Organogenesis
  • Pancreas / cytology
  • Pancreas / embryology
  • Pancreas / metabolism
  • Transcription Factors / metabolism


  • Transcription Factors