The effects of QX314 on thalamic neurons

Brain Res. 1985 May 6;333(2):350-4. doi: 10.1016/0006-8993(85)91591-4.


The effects of QX314 were studied in cat thalamic neurons recorded in vivo. Besides blocking Na+ spike electrogenesis, QX314 transformed spindle oscillations into a single long-lasting period of hyperpolarization that terminated with a rebound Ca2+ spike. Large sustained injections of the drug resulted in the occurrence of numerous fast prepotentials that had the characteristics of attenuated dendritic Ca2+ spikes. These effects are interpreted as resulting from the blockage by QX314 of a persistent Na+ current and a delayed rectifier K+ current which currents have already been disclosed in thalamic neurons recorded in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / physiology
  • Cats
  • Ion Channels / drug effects*
  • Lidocaine / analogs & derivatives*
  • Lidocaine / pharmacology
  • Membrane Potentials / drug effects
  • Potassium / physiology
  • Sodium / metabolism*
  • Thalamic Nuclei / drug effects*
  • Thalamic Nuclei / physiology


  • Ion Channels
  • QX-314
  • Lidocaine
  • Sodium
  • Potassium
  • Calcium