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Review
. 2015 Nov;151:2-12.
doi: 10.1016/j.mad.2015.03.006. Epub 2015 Mar 24.

MARK-AGE Biomarkers of Ageing

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Review

MARK-AGE Biomarkers of Ageing

Alexander Bürkle et al. Mech Ageing Dev. .

Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Keywords: Ageing biomarkers; Human studies; MARK-AGE.

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