Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Nov;151:2-12.
doi: 10.1016/j.mad.2015.03.006. Epub 2015 Mar 24.

MARK-AGE Biomarkers of Ageing


MARK-AGE Biomarkers of Ageing

Alexander Bürkle et al. Mech Ageing Dev. .


Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Keywords: Ageing biomarkers; Human studies; MARK-AGE.

Similar articles

  • Epigenetic and redox biomarkers: Novel insights from the MARK-AGE study.
    Moreno-Villanueva M, Bürkle A. Moreno-Villanueva M, et al. Mech Ageing Dev. 2019 Jan;177:128-134. doi: 10.1016/j.mad.2018.06.006. Epub 2018 Jun 30. Mech Ageing Dev. 2019. PMID: 29969595 Review.
  • MARK-AGE standard operating procedures (SOPs): A successful effort.
    Moreno-Villanueva M, Capri M, Breusing N, Siepelmeyer A, Sevini F, Ghezzo A, de Craen AJ, Hervonen A, Hurme M, Schön C, Grune T, Franceschi C, Bürkle A. Moreno-Villanueva M, et al. Mech Ageing Dev. 2015 Nov;151:18-25. doi: 10.1016/j.mad.2015.03.007. Epub 2015 Mar 26. Mech Ageing Dev. 2015. PMID: 25817206 Clinical Trial.
  • Biomarkes of aging.
    Vasto S, Scapagnini G, Bulati M, Candore G, Castiglia L, Colonna-Romano G, Lio D, Nuzzo D, Pellicano M, Rizzo C, Ferrara N, Caruso C. Vasto S, et al. Front Biosci (Schol Ed). 2010 Jan 1;2:392-402. doi: 10.2741/s72. Front Biosci (Schol Ed). 2010. PMID: 20036955 Review.
  • Novel ageing-biomarker discovery using data-intensive technologies.
    Griffiths HR, Augustyniak EM, Bennett SJ, Debacq-Chainiaux F, Dunston CR, Kristensen P, Melchjorsen CJ, Navarrete SA, Simm A, Toussaint O. Griffiths HR, et al. Mech Ageing Dev. 2015 Nov;151:114-21. doi: 10.1016/j.mad.2015.05.010. Epub 2015 Jun 6. Mech Ageing Dev. 2015. PMID: 26056714 Review.
  • MARK-AGE data management: Cleaning, exploration and visualization of data.
    Baur J, Moreno-Villanueva M, Kötter T, Sindlinger T, Bürkle A, Berthold MR, Junk M. Baur J, et al. Mech Ageing Dev. 2015 Nov;151:38-44. doi: 10.1016/j.mad.2015.05.007. Epub 2015 May 21. Mech Ageing Dev. 2015. PMID: 26004801
See all similar articles

Cited by 56 articles

See all "Cited by" articles

Publication types

LinkOut - more resources