Do all components of the metabolic syndrome cluster together in U.S. Hispanics/Latinos? Results from the Hispanic Community Health study/Study of Latinos

Ann Epidemiol. 2015 Jul;25(7):480-5. doi: 10.1016/j.annepidem.2015.02.010. Epub 2015 Feb 19.


Purpose: Metabolic syndrome (MetS), the clustering of several risk factors for cardiovascular disease, is highly prevalent in Hispanics/Latinos. We tested whether all components significantly loaded on the syndrome in Hispanics/Latinos and whether their contribution differed by sex and Hispanic ancestry. We also examined associations of MetS with prevalent diabetes and coronary heart disease in Hispanics/Latinos.

Methods: Data were obtained from a population-based cohort of n = 15,823 participants in the HCHS/SOL study who self-identified as being of Central American, Cuban, Dominican, Mexican American, Puerto Rican, or South American ancestry and were aged 18 to 74 years at screening.

Results: A latent variable model of waist circumference, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol (HDL-C), and fasting glucose fit the data in men and women, but the contribution of HDL-C was weak. No difference in the latent model of MetS was detected across Hispanic/Latino ancestry groups. MetS was significantly associated with diabetes and coronary heart disease.

Conclusions: Our results indicate that similar criteria for MetS may be applied across Hispanic/Latino ancestry groups but call into question the role of HDL-C in classifying the MetS in Hispanics/Latinos.

Keywords: Hispanics; Lipids; Metabolic syndrome.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Glucose
  • Blood Pressure
  • Cardiovascular Diseases / ethnology
  • Cluster Analysis
  • Coronary Disease / ethnology*
  • Diabetes Mellitus / ethnology*
  • Female
  • Hispanic or Latino*
  • Humans
  • Lipids / blood
  • Male
  • Metabolic Syndrome / ethnology*
  • Middle Aged
  • Prevalence
  • Risk Factors
  • Sex Factors
  • Socioeconomic Factors
  • United States / epidemiology
  • Waist Circumference
  • Young Adult


  • Blood Glucose
  • Lipids