Development of Ti-Nb-Zr alloys with high elastic admissible strain for temporary orthopedic devices

Sertan Ozan; Jixing Lin; Yuncang Li; Rasim Ipek; Cuie Wen

doi:10.1016/j.actbio.2015.03.023

Development of Ti-Nb-Zr alloys with high elastic admissible strain for temporary orthopedic devices

Acta Biomater. 2015 Jul:20:176-187. doi: 10.1016/j.actbio.2015.03.023. Epub 2015 Mar 25.

Authors

Sertan Ozan¹, Jixing Lin², Yuncang Li³, Rasim Ipek⁴, Cuie Wen⁵

Affiliations

¹ Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia; Department of Mechanical Engineering, Ege University, 35100 Bornova, Izmir, Turkey.
² Advanced Material Research and Development Center, Zhejiang Industry & Trade Vocational College, Wenzhou, Zhejiang 325003, China; Department of Materials Science and Engineering, Jilin University, Changchun, Jilin 130025, China.
³ School of Aerospace, Mechanical and Manufacturing Engineering, RMIT University, Melbourne, Victoria 3083, Australia.
⁴ Department of Mechanical Engineering, Ege University, 35100 Bornova, Izmir, Turkey.
⁵ Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia; School of Aerospace, Mechanical and Manufacturing Engineering, RMIT University, Melbourne, Victoria 3083, Australia. Electronic address: cuie.wen@rmit.edu.au.

PMID: 25818950
DOI: 10.1016/j.actbio.2015.03.023

Abstract

A new series of beta Ti-Nb-Zr (TNZ) alloys with considerable plastic deformation ability during compression test, high elastic admissible strain, and excellent cytocompatibility have been developed for removable bone tissue implant applications. TNZ alloys with nominal compositions of Ti-34Nb-25Zr, Ti-30Nb-32Zr, Ti-28Nb-35.4Zr and Ti-24.8Nb-40.7Zr (wt.% hereafter) were fabricated using the cold-crucible levitation technique, and the effects of alloying element content on their microstructures, mechanical properties (tensile strength, yield strength, compressive yield strength, Young's modulus, elastic energy, toughness, and micro-hardness), and cytocompatibilities were investigated and compared. Microstructural examinations revealed that the TNZ alloys consisted of β phase. The alloy samples displayed excellent ductility with no cracking, or fracturing during compression tests. Their tensile strength, Young's modulus, elongation at rupture, and elastic admissible strain were measured in the ranges of 704-839 MPa, 62-65 GPa, 9.9-14.8% and 1.08-1.31%, respectively. The tensile strength, Young's modulus and elongation at rupture of the Ti-34Nb-25Zr alloy were measured as 839 ± 31.8 MPa, 62 ± 3.6 GPa, and 14.8 ± 1.6%, respectively; this alloy exhibited the elastic admissible strain of approximately 1.31%. Cytocompatibility tests indicated that the cell viability ratios (CVR) of the alloys are greater than those of the control group; thus the TNZ alloys possess excellent cytocompatibility.

Keywords: Cytocompatibility; Elastic admissible strain; Mechanical properties; TNZ (Ti–Nb–Zr) alloys; Young’s modulus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alloys / pharmacology*
Cell Adhesion / drug effects
Cell Count
Cell Death / drug effects
Cell Line, Tumor
Cell Shape / drug effects
Cell Survival / drug effects
Compressive Strength / drug effects
Elastic Modulus / drug effects*
Hardness
Humans
Materials Testing / methods*
Orthopedic Equipment*
Tensile Strength / drug effects
X-Ray Diffraction

Substances

Alloys