The corallopyronins, new inhibitors of bacterial RNA synthesis from Myxobacteria

J Antibiot (Tokyo). 1985 Feb;38(2):145-52. doi: 10.7164/antibiotics.38.145.

Abstract

From the culture broth of the myxobacterium, Corallococcus (Myxococcus) coralloides, three new antibiotics have been isolated: corallopyronin A, B and C. The compounds, which are chemically related to the recently discovered myxopyronins, act mainly on Gram-positive bacteria, with MIC values between 0.1 and 10 micrograms/ml, and only exceptionally or at much higher concentrations (MIC values; 100 and more micrograms/ml) on Gram-negatives. They do not inhibit eukaryotic organisms and show no toxicity for mice (sc). The corallopyronins appear to block specifically eubacterial RNA polymerase.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / pharmacology
  • DNA, Bacterial / biosynthesis
  • DNA-Directed RNA Polymerases / antagonists & inhibitors
  • Gram-Positive Bacteria / drug effects
  • Mice
  • Microbial Sensitivity Tests
  • Myxococcales / metabolism*
  • RNA, Bacterial / biosynthesis*

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • RNA, Bacterial
  • DNA-Directed RNA Polymerases