Myosin-X and disease

Exp Cell Res. 2015 May 15;334(1):10-5. doi: 10.1016/j.yexcr.2015.03.014. Epub 2015 Mar 27.

Abstract

Myosin-X (Myo10) is a motor protein best known for its role in filopodia formation. New research implicates Myo10 in a number of disease states including cancer metastasis and pathogen infection. This review focuses on these developments with emphasis on the emerging roles of Myo10 in formation of cancer cell protrusions and metastasis. A number of aggressive cancers show high levels of Myo10 expression and knockdown of Myo10 has been shown to dramatically limit cancer cell motility in 2D and 3D systems. Myo10 knockdown also limits spread of intracellular pathogens marburgvirus and Shigella flexneri. Consideration is given to how these properties might arise and potential paths of future research.

Keywords: Cancer; Filopodia; Infectious disease; Metastasis; Myo10; Myosin-X.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Humans
  • Myosins / metabolism*
  • Neoplasms / metabolism*
  • Neoplasms / pathology

Substances

  • MYO10 protein, human
  • Myosins