The dynamic sclera: extracellular matrix remodeling in normal ocular growth and myopia development

Exp Eye Res. 2015 Apr;133:100-11. doi: 10.1016/j.exer.2014.07.015.


Myopia is a common ocular condition, characterized by excessive elongation of the ocular globe. The prevalence of myopia continues to increase, particularly among highly educated groups, now exceeding 80% in some groups. In parallel with the increased prevalence of myopia, are increases in associated blinding ocular conditions including glaucoma, retinal detachment and macular degeneration, making myopia a significant global health concern. The elongation of the eye is closely related to the biomechanical properties of the sclera, which in turn are largely dependent on the composition of the scleral extracellular matrix. Therefore an understanding of the cellular and extracellular events involved in the regulation of scleral growth and remodeling during childhood and young adulthood will provide future avenues for the treatment of myopia and its associated ocular complications.

Keywords: emmetropization; extracellular matrix; myopia; ocular development; sclera.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Extracellular Matrix / metabolism
  • Eye / growth & development*
  • Humans
  • Myopia / metabolism*
  • Myopia / physiopathology
  • Refraction, Ocular
  • Sclera / growth & development*