Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins

Int J Food Sci Nutr. 2015;66(4):395-9. doi: 10.3109/09637486.2015.1024208. Epub 2015 Mar 30.


Pomegranate (Punica granatum L.) has been used for centuries for the treatment of inflammatory diseases. However, there is a lack of comprehensive information focused on the properties of a certain pomegranate (poly)phenolic profile to cure pain and gastric injury induced by anti-inflammatory drugs. This study investigated the systemic effects of different doses of a HPLC-characterized pomegranate extract on the formalin-induced nociceptive behavior in mice. The effect of the extract against gastric injury caused by non-steroidal anti-inflammatory drugs and ethanol was also assessed. Pomegranate reduced nociception in both phases of the formalin test, suggesting central and peripheral activities to inhibit nociception. Indomethacin-induced gastric injury was not produced in the presence of pomegranate, which also protected against ethanol-induced gastric lesions. The present results reinforce the benefits of pomegranate (poly)phenolics in the treatment of pain as well as their anti-inflammatory properties.

Keywords: Anti-inflammatory; anthocyanin; antinociception; ellagitannin; formalin test; gastroprotection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / pharmacology*
  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Chromatography, High Pressure Liquid
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Hydrolyzable Tannins / pharmacology*
  • Lythraceae*
  • Male
  • Mice
  • Nociceptive Pain / drug therapy*
  • Plant Extracts / pharmacology*
  • Polyphenols / pharmacology


  • Analgesics
  • Anti-Inflammatory Agents
  • Hydrolyzable Tannins
  • Plant Extracts
  • Polyphenols
  • ellagitannin