This paper addresses the problems of synchronization and state estimation for a class of discrete-time hierarchical hybrid neural networks (NNs) with time-varying delays. The hierarchical hybrid feature consists of a higher level nondeterministic switching and a lower level stochastic switching. The latter is used to describe the NNs subject to Markovian modes transitions, whereas the former is of the average dwell-time switching regularity to model the supervisory orchestrating mechanism among these Markov jump NNs. The considered time delays are not only time-varying but also dependent on the mode of NNs on the lower layer in the hierarchical structure. Despite quantization and random data missing, the synchronized controllers and state estimators are designed such that the resulting error system is exponentially stable with an expected decay rate and has a prescribed H∞ disturbance attenuation level. Two numerical examples are provided to show the validity and potential of the developed results.