[Immunohistochemical demonstration of tumor-associated antigens in urinary bladder carcinomas using mono- and polyclonal antisera]

Onkologie. 1985 Apr;8(2):105-10. doi: 10.1159/000215630.
[Article in German]

Abstract

Keratin was found in more than 90% of transitional cell carcinomas of the bladder in the cytoplasma with polyclonal antibodies. Intensity increased with dedifferentiation. Cytokeratin was detected with monoclonal antibodies in more than 80%. Squamous cell carcinoma of the urinary bladder was always strongly positive for keratin and cytokeratin. CEA was found in 20% of G1 and 40% of G2 and G3 carcinomas of the urinary bladder. The prostatic epithelium markers PSA and PAP were always negative also Ca1.

Publication types

  • English Abstract

MeSH terms

  • Acid Phosphatase / analysis
  • Antibodies / analysis
  • Antigens, Neoplasm / analysis*
  • Carcinoembryonic Antigen / analysis
  • Carcinoma, Squamous Cell / immunology*
  • Carcinoma, Transitional Cell / immunology*
  • Humans
  • Immunoenzyme Techniques
  • Keratins / analysis
  • Male
  • Prostate / enzymology
  • Prostate-Specific Antigen
  • Urinary Bladder Neoplasms / immunology*

Substances

  • Antibodies
  • Antigens, Neoplasm
  • Ca1 antibody
  • Carcinoembryonic Antigen
  • Keratins
  • Acid Phosphatase
  • Prostate-Specific Antigen