The use of EEG parameters as predictors of drug effects on cognition

Eur J Pharmacol. 2015 Jul 15;759:163-8. doi: 10.1016/j.ejphar.2015.03.031. Epub 2015 Mar 28.


It has been shown to be difficult to predict whether cognition-enhancing effects of drugs in animal studies have the same effect in humans. Various issues in translating findings from animal to human studies can be identified. Here we discuss whether EEG could be considered as a possible tool to translate the effects of cognition enhancers across species. Three different aspects of EEG measures are evaluated: frequency bands, event-related potentials, and coherence analysis. On basis of the comparison of these measures between species, and effects of drugs that improve or impair memory performance (mainly cholinergic drugs), it appears that event-related potentials and coherence analyses could be considered as potential translational tools to study cognition-enhancing drug effects in rodents and animals.

Keywords: Cholinergic; Cognition; Coherence analysis; Drug research; Event-related potentials; Translational.

Publication types

  • Review

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Brain / drug effects*
  • Brain / physiopathology
  • Cognition / drug effects*
  • Drug Discovery
  • Electroencephalography*
  • Evoked Potentials / drug effects
  • Humans
  • Models, Animal*
  • Species Specificity
  • Translational Medical Research