Cerebral involvement in IgG4-related disease

Clin Med (Lond). 2015 Apr;15(2):130-4. doi: 10.7861/clinmedicine.15-2-130.


IgG4-related disease is a recently recognised multi-system disease. Common organ involvement includes the pancreas, biliary tree and salivary glands. Central nervous system involvement has been infrequently reported. In a single-centre cohort of 84 patients, we report cerebral involvement in three (4%) patients. Details of cerebral involvement in these patients are outlined, including pituitary involvement in two patients and a diffuse autoimmune-like encephalopathy in the other.

Keywords: Autoimmune pancreatitis; IgG4-related disease; encephalopathy; hypophysitis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Autoimmune Diseases / diagnosis*
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology
  • Brain Diseases / diagnosis
  • Brain Diseases / immunology
  • Brain Diseases / pathology
  • Female
  • Humans
  • Immunoglobulin G / immunology*
  • Male
  • Middle Aged
  • Pancreatitis / diagnosis*
  • Pancreatitis / immunology
  • Pancreatitis / pathology


  • Immunoglobulin G