Prognostic factors in malignant pleural mesothelioma

Hum Pathol. 2015 Jun;46(6):789-804. doi: 10.1016/j.humpath.2015.02.006. Epub 2015 Feb 28.


Malignant pleural mesothelioma (MPM) is a clinically aggressive tumor originating from mesothelial cells, which line the serosal cavities. Recent years have seen extensive research aimed at identifying new therapeutic targets, predictive markers and prognostic factors in this disease. These include both serum and tissue markers, and are related to multiple cellular pathways which affect cell survival, proliferation, apoptosis, angiogenesis, interaction with the immune response and DNA repair. Several of these molecules may become relevant for pathologists as part of the effort to select patient sub-populations for targeted therapy in the future. This review summarizes current data in this area and discusses their potential clinical relevance.

Keywords: Diagnosis; Malignant mesothelioma; Prognosis; Therapeutic targets; Tumor markers.

Publication types

  • Review

MeSH terms

  • Biomarkers / analysis*
  • Biomarkers, Tumor / metabolism*
  • Humans
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology
  • Mesothelioma / diagnosis*
  • Mesothelioma / metabolism
  • Mesothelioma / pathology
  • Mesothelioma, Malignant
  • Neovascularization, Pathologic / diagnosis*
  • Pleural Neoplasms / diagnosis*
  • Pleural Neoplasms / genetics
  • Pleural Neoplasms / pathology
  • Prognosis


  • Biomarkers
  • Biomarkers, Tumor