Lysophospholipid mediators in the vasculature

Exp Cell Res. 2015 May 1;333(2):190-194. doi: 10.1016/j.yexcr.2015.03.016. Epub 2015 Mar 28.


Acting through cell surface receptors, “extracellular” lysophosphatidic acid (LPA) influences cell growth, differentiation, apoptosis and development in a wide spectrum of settings [–5]. Within the vasculature, smooth muscle cells [6, 7], endothelial cells [8] and platelets [9, 10] display notable responses to LPA [11, 12], which likely regulate blood vessel development and contribute to vascular pathology. The bioactive effects of LPA are mediated by a family of G-protein coupled receptors with at least six members (termed LPA1-6 that are encoded by the LPAR genes in humans and Lpar in mice) [–3]. LPA may also serve as a ligand for the receptor for advanced glycation end products (RAGE) [13]. This review summarizes evidence to support a role for LPA signaling in vascular biology based on studies of LPA receptors and enzymes that produce or metabolize the lipid (Figure 1).

Keywords: Atherosclerosis; Autotaxin; Endothelial cells; Lipid phosphate phosphatase; Lysophosphatidic acid; Smooth muscle cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Atherosclerosis / metabolism
  • Blood Vessels / metabolism*
  • Blood Vessels / pathology
  • Cell Communication
  • Humans
  • Lysophospholipids / physiology*
  • Phosphoric Diester Hydrolases / metabolism
  • Receptors, Lysophosphatidic Acid / metabolism
  • Signal Transduction


  • Lysophospholipids
  • Receptors, Lysophosphatidic Acid
  • Phosphoric Diester Hydrolases
  • alkylglycerophosphoethanolamine phosphodiesterase
  • lysophosphatidic acid